Leishmania antimony resistance/ susceptibility in Algerian foci
نویسندگان
چکیده
منابع مشابه
Inhibition of ABC transporters abolishes antimony resistance in Leishmania Infection.
The emergence of antimony (Sb) resistance has jeopardized the treatment of visceral leishmaniasis in various countries. Previous studies have considered the part played by leishmanial parasites in antimony resistance, but the involvement of host factors in the clinical scenario remained to be investigated. Here we show that unlike infection with Sb-sensitive (Sbs) Leishmania donovani, infection...
متن کاملRetrospective and ongoing researches on Leishmania antimony resistance in Algeria
N. Eddaikra, K. Aït-Oudhia, B. Oury, Z. Harrat and D. Sereno Service d’eco-épidémiologie Parasitaire et Génétique des Populations Parasitologie, Institut Pasteur d'Algérie, Dely Ibrahim, Alger, Algeria. Ecole Nationale Supérieure Vétérinaire d’Alger, BP 161. Hassan Badi El-Harrach. Alger. Algeria. MIVEGEC (UM1-CNRS 5290-IRD 224) Institut de Recherche pour le Développement (IRD), BP 64501, 34394...
متن کاملMolecular mechanisms of antimony resistance in Leishmania Ashutosh
Leishmaniasis causes significant morbidity and mortality worldwide. The disease is endemic in developing countries of tropical regions, and in recent years economic globalization and increased travel have extended its reach to people in developed countries. In the absence of effective vaccines and vector-control measures, the main line of defence against the disease is chemotherapy. Organic pen...
متن کاملAntimony Resistance in Leishmania, Focusing on Experimental Research
Leishmaniases are parasitic diseases that spread in many countries with a prevalence of 12 million cases. There are few available treatments and antimonials are still of major importance in the therapeutic strategies used in most endemic regions. However, resistance toward these compounds has recently emerged in areas where the replacement of these drugs is mainly limited by the cost of alterna...
متن کاملA novel marker, ARM58, confers antimony resistance to Leishmania spp.☆
Protozoa of the Leishmania genus cause a variety of disease forms that rank at the top of the list of neglected tropical diseases. Anti-leishmanial drugs based on pentavalent antimony have been the mainstay of therapy for over 60 years and resistance against them is increasingly encountered in the field. The biochemical basis for this is poorly understood and likely diverse. No stringent correl...
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ژورنال
عنوان ژورنال: Open Journal of Tropical Medicine
سال: 2017
ISSN: 2640-8147
DOI: 10.17352/ojtm.000005